|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We tested TGF-beta1 single-nucleotide polymorphisms (SNPs) at position +869 of codon 10 (leucine or proline) and position +915 of codon 25 (arginine or proline) for association with irreversible bronchoconstriction in a case-control study involving 110 patients with asthma and 109 controls.
|
19046298 |
2008 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We sought to evaluate the association of TGF-β1 -509 C/T promoter variant with clinical asthma and varying degrees of disease severity.
|
25359706 |
2015 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) and four IgE response genes (IL4, IL13, IL4RA, and STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma and allergy in Karelian children.
|
21749458 |
2011 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
We hypothesized that the effects of functional TGF-beta1 variants on asthma occurrence vary by these exposures.
|
17673695 |
2007 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that the effects of functional TGF-beta1 variants on asthma occurrence vary by these exposures.
|
17673695 |
2007 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We hypothesized that MIF induces transforming growth factor-β1 (TGF-β1) synthesis, which has been shown to play an important role in asthma and airway remodeling.
|
20485865 |
2010 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We hypothesized that TGF-beta1 (innate response factor associated with wound repair) in combination with IL-13 (Th2 factor) might augment inflammatory processes associated with asthma.
|
12370400 |
2002 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We found that both UII and TGF-β1 were upregulated in asthma lung tissues.
|
22270542 |
2012 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We found significantly decreased Bcl11b but increased IL-17A and TGF-β1 expression in patients with asthma and a strongly negative correlation between Bcl11b and these 2 cytokines in SA patients.
|
30088373 |
2018 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We examined TGFB1 SNPs in relation to asthma risk and degree of atopy among 546 case-parent triads, consisting of asthmatics aged 4-17 years and their parents in Mexico City.
|
17333284 |
2007 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
We examined TGFB1 SNPs in relation to asthma risk and degree of atopy among 546 case-parent triads, consisting of asthmatics aged 4-17 years and their parents in Mexico City.
|
17333284 |
2007 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We designed this study to evaluate relation between Transforming Growth Factor Beta1 (TGFß1) and Tissue Inhibitory of Metaloproteinase 2 (TIMP2) as two main tissue mediators on activity and reversibility of asthma and chronic obstructive pulmonary disease (COPD).
|
20683101 |
2010 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the T allele of C-509T is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription.
|
14597484 |
2004 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
LHGDN |
Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis.
|
18359288 |
2008 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
To evaluate main effects and gene-gene interactions of haplotype tagging single nucleotide polymorphisms of genes involved in regulatory T-cell function-IL6, IL6R, IL10, heme-oxygenase 1 (HMOX1), IL2, Toll-like receptor 2 (TLR2), TGFB1, TGF-beta receptor (TGFBR)-1, TGFBR2, IL2RA, and forkhead box protein 3 (FOXP3)-in relation to atopy and asthma.
|
20599261 |
2010 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To derive a more precise estimation of the relationship between the T869C and C-509T polymorphisms of the TGF-β1 gene and asthma, a meta-analysis of 24 published case-control studies was conducted.
|
24269701 |
2014 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Through our review, we aim to further elucidate the role of TGF-β1 in asthma pathogenesis and the link between airway remodeling and airway hyperresponsiveness in asthma and to define TGF-β1 as a potential therapeutic target for reducing asthma morbidity and mortality.
|
27854509 |
2017 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study examines the signaling pathways leading to TGFβ1 induced IL-6 and IL-8 in primary HBE cells from asthmatic and non-asthmatic volunteers.
|
20607798 |
2010 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study evaluated the role and frequency of genetic polymorphisms (C-509T, C+466T and T+869C) of the TGF-β1 gene in the study group (patients with asthma) and the control group (healthy volunteers).
|
25119113 |
2014 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study compared the expression of PI3K isoforms by ASM cells from donors with asthma (A), chronic obstructive pulmonary disease (COPD), or neither disease (NA), and investigated the role of PI3K isoforms in the production of TGFβ1 induced pro-inflammatory cytokine and contractile proteins in ASM cells.
|
22015454 |
2012 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that TGF-β1 C-509T and T869C polymorphisms may be risk factors for asthma.
|
27717847 |
2016 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
LHGDN |
This is the first report to suggest a functional role for Nox4 in cell cycle transition and to demonstrate that Nox4 influences the pathobiochemistry of asthma by generating reactive oxygen species that promote TGF-beta1-induced proliferation and hypertrophy of human airway smooth muscle.
|
17369289 |
2007 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
These studies demonstrate that GSDMB, a gene highly linked to asthma but whose function in asthma is previously unknown, regulates AHR and airway remodeling without airway inflammation through a previously unrecognized pathway in which GSDMB induces 5-LO to induce TGF-β1 in bronchial epithelium.
|
27799535 |
2016 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
These results indicated that TGF beta 1 mRNA was overexpressed in severe asthmatics and that the main source of the mRNA was eosinophils, suggesting that eosinophils play an important role in the pathogenesis not only of inflammation but also of structural changes, such as subepithelial fibrosis, in asthmatic airways.
|
8810646 |
1996 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
These data suggest that NE upregulates TGF-beta1 gene expression and release via My88/IRAK/NF-kappaB pathway, possibly through activation of TLR4, and shed light on a potential role of neutrophils in the pathogenesis of asthma.
|
16690986 |
2006 |